Version 5 of the second metabolite tool #antiSMASH has been redesigned and extended. The new UI and greatly reduced runtimes make it possible to deliver annotations for bacterial genomes within a few minutes. Furthermore detection rules for clusters encoding #biosynthesis of #acylaminoacids, #betalactones, #RiPPs, polybrominated diphenyl ethers, C-nucleosides, PPY-like ketones and lipolanthines and a direct link to the antiSMASH database . The paper describing the updates has just been published in Nucleic Acids Research antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline