NEW METABOLITES PRODUCED FROM A RARE ACTINOMYCETE

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As part of the iimena project, we are investigating the genomes, as well as the metabolite profiles of many actinomycete strains. Despite the well-known Streptomyces, there are other underexplored genera in the phylum of Actinobacteria that are very promising on producing new, complex specialized metabolites. Through a combined genetic and metabolite approach, we investigated a rare Kutzneria strain that proved to produce two novel macrolides, epemicins A and B. The work, that is now published in ACS Chemical Biology, was a collaboration between the chemistry team of the iimena project, that isolated and structurally elucidated the new compounds, as well as the genome mining and engineering team, that managed to link epemicins to the gene cluster responsible for their biosynthesis. Link to the paper: Discovery and Characterization of Epemicins A…
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IIMENA Project Half-Annual Meeting

IIMENA Project Half-Annual Meeting

News
Today we had the iimena annual scientific project meeting, again online due to the COVID-19 situation, with all the partners from the IIMENA project funded by a Challenge Grant of the Novo Nordisk Foundation. The meeting allowed the partners to present their latest update on the results from the project as well as the next steps and plans for the future. We hope the next meeting towards the end of the year 2021 will be face-to-face.
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