New CRISPR-prime editing toolkit to engineer E. coli

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Scientists from DTU Biosustain and KAIST funded by Novo Nordisk Foundation and part of the iimena project have developed a new CRISPR-prime editing toolkit to engineer E. coli. Have a look at the Nature Communications paper -> A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing. nature Communications. 2021. DOI:10.1038/s41467-021-25541-3
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NEW METABOLITES PRODUCED FROM A RARE ACTINOMYCETE

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As part of the iimena project, we are investigating the genomes, as well as the metabolite profiles of many actinomycete strains. Despite the well-known Streptomyces, there are other underexplored genera in the phylum of Actinobacteria that are very promising on producing new, complex specialized metabolites. Through a combined genetic and metabolite approach, we investigated a rare Kutzneria strain that proved to produce two novel macrolides, epemicins A and B. The work, that is now published in ACS Chemical Biology, was a collaboration between the chemistry team of the iimena project, that isolated and structurally elucidated the new compounds, as well as the genome mining and engineering team, that managed to link epemicins to the gene cluster responsible for their biosynthesis. Link to the paper: Discovery and Characterization of Epemicins A…
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IIMENA Project Half-Annual Meeting

IIMENA Project Half-Annual Meeting

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Today we had the iimena annual scientific project meeting, again online due to the COVID-19 situation, with all the partners from the IIMENA project funded by a Challenge Grant of the Novo Nordisk Foundation. The meeting allowed the partners to present their latest update on the results from the project as well as the next steps and plans for the future. We hope the next meeting towards the end of the year 2021 will be face-to-face.
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CPH Bioscience Lecture: The AMR Challenge – Mining soils for drugs – Microbes as source for novel antibiotics

CPH Bioscience Lecture: The AMR Challenge – Mining soils for drugs – Microbes as source for novel antibiotics

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On 25th February 2021 at the Novo Nordisk Foundation, professor Tilmann Weber had a pleasure to give a fantastic talk with title Mining soils for drugs – Microbes as source for novel antibiotics as part of the CPH Bioscience lecture. He presented the newest research result from his group at CFB as well as from the IIMENA project where he has a role of coordinator.
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Finding new antibiotics: The genome way

Finding new antibiotics: The genome way

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The iimena project funded by a Challenge Grant by the Novo Nordisk Foundation integrates BGC discovery with innovative high throughput screening, adaptive laboratory evolution and metabolic engineering using newest technologies available, to tap into the secret world of active compounds produced by bacteria and fungi to reveal the next generation of antibiotics. Read the full article here .
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