A research group at KAIST presented a novel biosensor which can produce diverse, high-level microbial cell factories. The biosensor monitors the concentration of products and even intermediates when new strains are being developed. This strategy provides a new platform for manufacturing diverse natural products from renewable resources. The team succeeded in creating four natural products of high-level pharmaceutical importance with this strategy. This article was published so far at three different places. Find them below. - KAIST news - EurekAlert - ScienceDaily
We are looking forward to host the 3rd International Workshop for early career scientists on Genome Mining for Natural Products, which will take place from 12.-14. September at DTU Biosustain. 30 participants from 8 different countries will get two days of intensive training using the state of the art bioinformatics tools antiSMASH and NORINE and will have the opportunity to directly interact with the developers of the software.
Scientists working in the iimena-project just published a review article on the potential of genome-scale metabolic reconstructions for optimizing antibiotics biosynthesis in actinomycetes. The article, which was published in the "Biotechnolgy J." can be downloaded here or requested from the authors.
Applications are open for the 15th Copenhagen Bioscience Conference "Averting the post-antibiotic era- challenges and developments" from Oct 31-Nov 3. Application deadline is June 17th. Find more information about the how to apply and register here. Click here to see the flyer -> Copenhagen Bioscience Conference
The first annual meeting of the IIMENA project funded by a Challenge Grant of the Novo Nordisk Foundation was held in Copenhagen, Denmark on 17th of April, 2018. The meeting was hosted by the Technical University of Denmark, a coordinating partner of the consortium. The meeting allowed the partners to present what they have done in the first year as well as the next steps and plans for the years to come.
The picture shows the result of the confrontation between an endophytic fungus, living inside plant tissues and a phytopathogen using a co-culture technique. It allows the in vitro simulation of microorganism’s interactions that may happen in their natural environment. The endophytic species Dothiora sp. (black fungi) faced the phytopathogen strain Hypoxylon mediterraneum (white fungi) for 14th days in a Petri plate and an agar environment at 22ºC. Both microorganisms might be detecting each other’s presence through the diffusion of environmental signals, generating an antagonistic reaction that inhibits the phytopathogen growth. We can observe how the H. mediterraneum´s hyphas are restrained and cannot invade its opponent. New studies have recently demonstrated the relevancy of this technique for the induction of new secondary metabolites. Find more information here.