The iimena project funded by a Challenge Grant by the Novo Nordisk Foundation integrates BGC discovery with innovative high throughput screening, adaptive laboratory evolution and metabolic engineering using newest technologies available, to tap into the secret world of active compounds produced by bacteria and fungi to reveal the next generation of antibiotics. Read the full article here .
An important aim of the iimena project is to develop methods that enable us to more efficiently get access to the potential new antibiotics produced by actinomycetes. One of the most important developments in the recent years have been molecular tools using CRISPR technologies. iimena scientists have been on the forefront of developing such tools and sharing them with the international research community. We are therefore very happy that a protocol now has been published in Nature Protocols. In the publication, titled "CRISPR–Cas9, CRISPRi and CRISPR-BEST-mediated genetic manipulation in streptomycetes", users of the toolkit find very detailed step-by-step guides on how to most efficiently use our toolkit. Link to the protocol:Tong, Y. et al. CRISPR-Cas9, CRISPRi and CRISPR-BEST-mediated genetic manipulation in streptomycetes. Nat. Protoc., doi:10.1038/s41596-020-0339-z (2020). Link to interactive PDF…
Today we had the iimena annual scientific project meeting, this time online due to the COVID-19 situation, with all the partners from the IIMENA project funded by a Challenge Grant of the Novo Nordisk Foundation. The meeting allowed the partners to present their latest update on the results from the project as well as the next steps and plans for the future. We had the pleasure to introduce 3 new DTU team members and each of them had a short presentation on their projects.
Olga Genilloud the Scientific Director of Fundación MEDINA in Granada Spain, was a speaker at the B-Debate Reversing a dystopian future - New strategies to discover antibacterial agents from 12-14 November in Barcelona, Spain. She had a talk about Secondary metabolites with antibacterial activity.
Tue Sparholt Jørgensen, Postdoc fellow at DTU Biosustain Center for Biosustainability participated at the Annual Congress of The Danish Microbiological Society on 11th November in Copenhagen, Denmark. He presented a poster with title: Actinobacteria: Genome Sequencing and Assembly with contribution from his colleagues Tetiana Gren, Kai Blin, Oliwia Durczak, Simon Shaw, and Tilmann Weber.
Xinglin Jiang, Researcher at DTU Biosustain Center for Biosustainability participated at the 8th National Infection Biology Meeting in Kalmarsand, Sweden from 14th - 15th October in Kalmarsand, Sweden where he had a talk with title: Dissemination of antibiotic resistance genes from antibiotic producers to pathogens.
Congratulations to Omkar Mohite who third time in a row won an "Best Presentation" award on his #pangenome analysis of Enterobacteria at the Synthetic and Systems Biology Summer School in Pisa, Italy in July. He received the great news yesterday after couple of months waiting and he said: Better late than never! :-) Check the details here .
The European Researchers Night is an event coordinated by the European Commission aiming at bringing together researchers and society in cities around the world. The Granada 2019 edition took place on 27th September and involved over 500 researchers performing hands-on experiments and practical workshops. The aim is also to motivate young people to embark on research careers. The events promote how researchers contribute to our society by displaying their work in an interactive and engaging forum. Fundación MEDINA participated in the event with a workshop where people had the chance to learn the crucial role played by microbial natural products to combat infectious diseases, and the importance of R&D projects such as IIMENA to discover new antibiotics. Video of the event is available at https://www.youtube.com/watch?v=bioJelEdvHg&feature=youtu.be