Today at MEDINA premises in Granada Spain, we had the second annual scientific project meeting with all the partners from the IIMENA project funded by a Challenge Grant of the Novo Nordisk Foundation. The meeting allowed the partners to present their latest update on the results from the project as well as the next steps and plans for the years to come.
Version 5 of the second metabolite tool #antiSMASH has been redesigned and extended. The new UI and greatly reduced runtimes make it possible to deliver annotations for bacterial genomes within a few minutes. Furthermore detection rules for clusters encoding #biosynthesis of #acylaminoacids, #betalactones, #RiPPs, polybrominated diphenyl ethers, C-nucleosides, PPY-like ketones and lipolanthines and a direct link to the antiSMASH database . The paper describing the updates has just been published in Nucleic Acids Research antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
Today at the Center for Biosustainability at DTU premises in Lyngby Denmark, we had a great scientific meeting with all the partners from the IIMENA project funded by a Challenge Grant of the Novo Nordisk Foundation. In the afternoon, we had a Site Visit from representatives from the Novo Nordisk Foundation where we presented the idea and results from the project so far as well as the plans for the years to come.
He recently presented highlights of our work from Genome-scale Metabolic Modeling package of IIMENA project at COBRA conference in Seattle, USA from 14-16 October, 2018. We are developing modeling tools with specific attention towards biosynthesis of secondary metabolites. These tools can add unique value allowing to expand applications of fast growing COBRA methods to improve production of antibiotics. It was very inspiring to listen to talks and poster presentations from some of the leaders in this highly relevant field to his PhD project.
A research group at KAIST presented a novel biosensor which can produce diverse, high-level microbial cell factories. The biosensor monitors the concentration of products and even intermediates when new strains are being developed. This strategy provides a new platform for manufacturing diverse natural products from renewable resources. The team succeeded in creating four natural products of high-level pharmaceutical importance with this strategy. This article was published so far at three different places. Find them below. - KAIST news - EurekAlert - ScienceDaily
The European Researchers Night is an event coordinated by the European Commission aiming at bringing together researchers and society in cities around the world. The Granada 2018 edition took place on 28th September and involved over 500 researchers performing hands-on experiments and practical workshops. Fundacion MEDINA participated in the event with a workshop where people had the chance to learn the crucial role played by microbial natural products to combat infectious diseases, and the importance of R&D projects such as IIMENA to discover new antibiotics. Video of the event available here.
We are looking forward to host the 3rd International Workshop for early career scientists on Genome Mining for Natural Products, which will take place from 12.-14. September at DTU Biosustain. 30 participants from 8 different countries will get two days of intensive training using the state of the art bioinformatics tools antiSMASH and NORINE and will have the opportunity to directly interact with the developers of the software.