Scientists from DTU Biosustain and KAIST funded by Novo Nordisk Foundation and part of the iimena project have developed a new CRISPR-prime editing toolkit to engineer E. coli. Have a look at the Nature Communications paper -> A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing. nature Communications. 2021. DOI:10.1038/s41467-021-25541-3
As part of the iimena project, we are investigating the genomes, as well as the metabolite profiles of many actinomycete strains. Despite the well-known Streptomyces, there are other underexplored genera in the phylum of Actinobacteria that are very promising on producing new, complex specialized metabolites. Through a combined genetic and metabolite approach, we investigated a rare Kutzneria strain that proved to produce two novel macrolides, epemicins A and B. The work, that is now published in ACS Chemical Biology, was a collaboration between the chemistry team of the iimena project, that isolated and structurally elucidated the new compounds, as well as the genome mining and engineering team, that managed to link epemicins to the gene cluster responsible for their biosynthesis. Link to the paper: Discovery and Characterization of Epemicins A…
Today we had the iimena annual scientific project meeting, again online due to the COVID-19 situation, with all the partners from the IIMENA project funded by a Challenge Grant of the Novo Nordisk Foundation. The meeting allowed the partners to present their latest update on the results from the project as well as the next steps and plans for the future. We hope the next meeting towards the end of the year 2021 will be face-to-face.
Postdoctoral fellow Tue Sparholt Jørgensen and researcher Kai Blin from DTU Biosustain, Center for Biosustainability, were part of the team who found the Brazilian variant of the coronavirus using the Sanger sequencing protocol which was developed by Tue S. Jørgensen. Read the full article here .
On 25th February 2021 at the Novo Nordisk Foundation, professor Tilmann Weber had a pleasure to give a fantastic talk with title Mining soils for drugs – Microbes as source for novel antibiotics as part of the CPH Bioscience lecture. He presented the newest research result from his group at CFB as well as from the IIMENA project where he has a role of coordinator.
Professor Tilmann Weber will be one of the speakers at the CPH Bioscience lecture on 25th February, 2021. This event will be online, therefore registration is mandatory. Please follow the link below and find more inforamtion about the event, the other speakers and much more. Copenhagen Bioscience Lecture: The AMR Challenge.