The picture shows the result of the confrontation between an endophytic fungus, living inside plant tissues and a phytopathogen using a co-culture technique. It allows the in vitro simulation of microorganism’s interactions that may happen in their natural environment. The endophytic species Dothiora sp. (black fungi) faced the phytopathogen strain Hypoxylon mediterraneum (white fungi) for 14th days in a Petri plate and an agar environment at 22ºC. Both microorganisms might be detecting each other’s presence through the diffusion of environmental signals, generating an antagonistic reaction that inhibits the phytopathogen growth. We can observe how the H. mediterraneum´s hyphas are restrained and cannot invade its opponent. New studies have recently demonstrated the relevancy of this technique for the induction of new secondary metabolites. Find more information here.
On Feb 9th, four DTU scientists met at Fundación Medina in Granada to discuss the progress of the screening-related work packages of the iimena Challenge Grant project. “It is great to see the progress of our project and the interaction of our groups”, says Tilmann Weber, the iimena coordinator. “I’m really excited now on the next steps, where we will determine the full genome sequences of the strains that were so far identified in the screenings against our panel of clinical pathogens and perform Genome Mining studies on these strains”.
Fundación MEDINA keeps working on the investigation of new antibiotics and is one of the three participants of the Project IIMENA “Integration of Informatics and Metabolic Engineering for the discovery of Novel Antibiotics” financed by the Novo Nordisk Foundation. This new 7.7 M euros research program is led by the new center DTU-Biosustain (Novo Nordisk Foundation Center for Biosustainability) of the Technical University of Denmark and counts with the active participation of Fundación MEDINA and KAIST, the Korea Advanced Institute for Science and Technology. Find more information here.